WEBERNEEDLE ENDOLASER
WEBER Laser is an advanced Low-Level Laser Therapy (LLLT) technology used for therapeutic and regenerative purposes. The WEBER system uses medical laser diodes with a standard power output of approximately 2 mW, delivered directly into the bloodstream through a sterile optical fibre inserted into a vein using a fine catheter.
This innovative method allows the use of personalised combinations of six medical laser colours—red, blue, green, yellow, ultraviolet, and infrared—with each colour having specific therapeutic indications and different biological mechanisms.
How does WEBER Laser work?
WEBER intravenous laser therapy involves the direct irradiation of the blood using laser light at precise wavelengths. The light is transmitted through a sterile optical fibre inserted into a peripheral vein, usually in the upper arm or forearm.
Unlike conventional transdermal laser therapy, in which more than 70% of the energy is lost at skin level, the WEBERneedle® Endolaser delivers laser energy directly into the bloodstream, without energy loss, enabling the activation of systemic biological processes:
▪️ activation of cellular metabolism
▪️ stimulation of mitochondrial function
▪️ improvement of microcirculation
▪️ regulation of the immune response
▪️ support for regeneration and detoxification processes
Specifications / functions / technologies
▪️ Low-Level Laser Therapy (LLLT)
Laser diode with a power output of approximately 2 mW
Safe for repeated clinical use
▪️ Intravenous Laser Blood Irradiation (ILBI)
Sterile optical fibre inserted into a vein
Minimally invasive procedure
▪️ Six colours of therapeutic laser diodes
Red
Green
Blue
Yellow
Ultraviolet
Infrared
▪️ Personalised colour combinations
Adapted according to the condition and therapeutic objective
▪️ Weberneedle® Endolaser / Lasercath technology
Precise delivery of laser energy without energy loss
Optical fibres and cannulas measuring up to 12 cm
▪️ Compatibility with additional therapies
Intravenous infusions
Photodynamic therapy (PDT)
▪️ Multiple applications
Intravenous
Intra-articular
Regenerative and anti-inflammatory
▪️ Learn more about Intravenous Laser Therapy
Methods of use
WEBER Laser may be used in:
▪️ Intravenous Laser Blood Irradiation (ILBI)
▪️ Intra-articular therapy for joints and nerves
▪️ Photodynamic therapy (PDT)
▪️ Therapy combined with intravenous infusions, including vitamins, NAD+, and natural substances
▪️ Integrative medicine, lifestyle, and longevity programmes
Session duration: 20–60 minutes
Number of sessions: usually 5–10, depending on the condition
Frequency: daily or at intervals of up to seven days
Therapeutic effects of the laser colours
Effects of the red laser
Improves the rheological properties of the blood
Reduces platelet aggregation
Increases erythrocyte deformability
Activates the phagocytic function of macrophages
Stimulates lymphocyte and B-cell proliferation
Increases IgG, IgM, cytokine, interferon, and interleukin levels
Increases ATP production by activating cytochrome C
Reduces tissue hypoxia
Activates fibrinolysis
Provides analgesic, antispasmodic, and sedative effects
Provides antitumour effects
Activates adult stem cells
Improves microcirculation within central nervous system structures
Effects of the green laser
Binds to haemoglobin
Improves erythrocyte elasticity and function
Increases oxygen delivery to tissues
Reduces lactic acid
Activates cellular repair pathways
Stimulates platelets
Regulates the sodium–potassium pump
Increases ATP production by more than 30%
Reduces blood viscosity
Effects of the blue laser
Releases nitric oxide (NO)
Promotes vasodilation and improves endothelial function
Lowers blood pressure
Provides analgesic and anti-inflammatory effects
Reduces pro-inflammatory cytokines
Provides antimicrobial activity against bacteria and viruses
Provides a detoxifying effect
Activates telomerase, producing an anti-ageing effect
Stimulates adult stem cells
When combined with curcumin, it provides an antitumour effect
Effects of the yellow laser
Regulates the hormonal system
Improves the enzymatic antioxidant system
Provides a detoxifying effect
Provides strong antidepressant effects
Reduces chronic pain
Supports vitamin D metabolism
Improves bone and immune health
Increases serotonin production
Useful for anxiety, panic attacks, and chronic fatigue
Effects of the ultraviolet laser
Strengthens the immune system
Provides antiviral, antibacterial, and antifungal effects
Activates immune defence mechanisms
Supports the body’s detoxification processes
Normalises lipid metabolism
Activates cortisone molecules and sterols
Improves overall well-being
Effects of the infrared laser
Penetrates deep into tissues, reaching a depth of 6–7 cm
Reaches bone structures
Increases cellular activity
Improves microcirculation
Regenerates damaged tissues
Provides analgesic and antispasmodic effects
Useful in regenerative therapies and stem cell therapy
What advantages and benefits does WEBER Laser provide?
▪️ Direct delivery of laser energy into the bloodstream
▪️ Greater efficiency than transdermal laser therapy
▪️ Personalised treatment through customised colour combinations
▪️ Reduction of systemic inflammation
▪️ Improvement of circulation and tissue oxygenation
▪️ Stimulation of the immune system
▪️ Support for cellular regeneration
▪️ Minimally invasive and well-tolerated procedure
▪️ Compatibility with intravenous infusions and photodynamic therapy
▪️ Broad applicability in circulatory, neurological, inflammatory, and metabolic conditions
Medical device classification – WEBER Laser (intravenous LLLT laser)
WEBER Laser is classified as a Class IIb active medical device under the European Medical Device Regulation (MDR – EU 2017/745) and, previously, Directive 93/42/EEC.
This classification is justified by the following aspects:
▪️ it is an active invasive medical device used by inserting a sterile optical fibre into a peripheral vein;
▪️ it acts directly on the blood and biological systems through intravenously applied laser energy;
▪️ it influences essential physiological functions, including microcirculation, cellular metabolism, immune response, and regenerative processes;
▪️ it is intended for use in medical clinics, integrative medicine centres, and specialised medical practices, exclusively under medical supervision;
▪️ it involves a moderate to high level of risk, specific to invasive devices with systemic effects;
▪️ it complies with strict standards regarding optical safety, energy control, accessory sterility, and risk management.
The Class IIb CE certification confirms that WEBER Laser is a professional medical device intended for therapeutic clinical applications rather than wellness or cosmetic use.
Scientific basis and clinical studies
WEBER Medical is a German company with more than 20 years of experience in Low-Level Laser Therapy. WEBER systems are used in over 2,000 clinics and medical practices worldwide.
Research in the fields of LLLT and ILBI has demonstrated:
▪️ improved microcirculation
▪️ increased ATP production
▪️ modulation of the immune response
▪️ reduced inflammation and pain
Weberneedle® Endolaser technology addresses one of the main limitations of conventional laser therapy: energy loss at skin level. Through the intravenous or intra-articular approach, laser energy acts directly at the deep cellular and tissue levels.
WEBER Medical conducts its manufacturing, servicing, and development activities in Germany, while Dr Weber’s clinical work enables the rapid integration of the latest scientific discoveries into medical practice. Learn more – HERE
1. Intravenous laser therapy and microcirculation
Title: Intravenous Laser Blood Irradiation: Current Evidence
Summary: The study highlights improvements in microcirculation, reduced blood viscosity, and increased erythrocyte deformability following intravenous laser therapy.
Link: https://pubmed.ncbi.nlm.nih.gov/24851307/
2. LLLT and the stimulation of cellular metabolism
Title: Low-Level Laser Therapy and Mitochondrial Function
Summary: The research demonstrates that LLLT stimulates mitochondrial function by activating cytochrome C oxidase, increasing ATP production, and supporting cellular regeneration.
Link: https://pubmed.ncbi.nlm.nih.gov/21766571/
3. Effects of laser therapy on the immune system
Title: Immunomodulatory Effects of Low-Level Laser Therapy
Summary: The study shows that LLLT may modulate the immune response by activating macrophages, increasing cytokine production, and stimulating lymphocytes.
Link: https://pubmed.ncbi.nlm.nih.gov/19500270/
4. Laser therapy and the reduction of systemic inflammation
Title: Anti-Inflammatory Mechanisms of Low-Level Laser Therapy
Summary: The analysis confirms reductions in inflammatory markers and pain through photobiomodulatory mechanisms, including nitric oxide release and regulation of pro-inflammatory cytokines.
Link: https://pubmed.ncbi.nlm.nih.gov/26699163/
5. Intravenous laser therapy for chronic conditions
Title: Clinical Applications of Intravenous Laser Therapy in Chronic Diseases
Summary: The clinical study reports benefits in chronic inflammatory, circulatory, and metabolic conditions, alongside improved overall well-being and good tolerability.
Link: https://pubmed.ncbi.nlm.nih.gov/30741522/
6. Intravenous laser therapy (ILIB) – recent randomised controlled trials
Title: Effects of Intravenous Laser Blood Irradiation with Red and Blue Light on Stroke Risk Biomarkers and Neurological Function: A Double-Blind Randomized Controlled Trial
Summary: A randomised, double-blind study published in 2025 evaluated the effects of ILIB using red and blue light on stroke risk biomarkers and neurological function. The results showed significant improvements in vascular and neurological parameters, supporting the potential of ILIB therapy to optimise microcirculation and neurovascular function.
Publication: Lasers in Medical Science, 2025
7. Intravenous laser therapy for knee osteoarthritis – effects on inflammatory cytokines
Title: Intravenous Laser Blood Irradiation Modulates Inflammatory Cytokines in Knee Osteoarthritis
Summary: A study published in 2024 investigated the effects of ILIB on pro-inflammatory cytokines in patients with knee osteoarthritis. The results indicated significant reductions in inflammatory markers such as IL-1β and IL-13, correlated with reduced pain and improved joint function.
Publication: International Journal of Molecular Sciences, 2024
8. Registered clinical studies – intravenous laser therapy
Several randomised controlled trials are currently underway and registered on ClinicalTrials.gov, evaluating the effectiveness and safety of intravenous laser therapy (ILIB) in musculoskeletal and chronic inflammatory conditions, including osteoarthritis. These studies assess clinical and inflammatory parameters, as well as quality of life, contributing to the expansion of the clinical evidence base.
9. Systematic reviews and summaries of ILIB clinical studies
Title: Intravenous Laser Blood Irradiation: Principles, Mechanisms and Clinical Applications
Summary: A systematic review published in 2025 analysing the physical principles, biological mechanisms, and clinical applications of ILIB therapy. The authors conclude that the existing clinical evidence supports beneficial effects on microcirculation, inflammation, and oxidative stress, while also emphasising the need to standardise protocols and conduct additional randomised controlled trials.
Publication: PubMed, 2025
10. ILIB effectiveness and safety – review of RCTs
Title: Efficacy and Safety of Intravenous Laser Blood Irradiation: A Review of Randomized Controlled Trials
Summary: A review article focusing on randomised controlled trials that evaluates the effectiveness and safety of ILIB therapy in reducing pain, inflammation, and oxidative stress and improving quality of life. The results indicate a favourable safety profile and moderate clinical benefits, particularly when used as an adjunctive therapy.
Publication: ScienceDirect, 2025