TEST METABOLOMIX PLUS
Metabolomix+ is a unique combination of advanced nutritional tests that provides a comprehensive analysis of the main functional and nutritional biomarkers in the body. The Metabolomix+ test is a non-invasive and patient-friendly method used to assess the functional need for antioxidants, B-complex vitamins, minerals, amino acids, digestive support, as well as urinary elements (add-on) and fatty acids (add-on).
Test price: 4,970 RON
Interpretation price: 620 RON
The Metabolomix+ profile represents the most comprehensive functional and nutritional assessment available. It is designed to help practitioners identify the root causes of dysfunctions and treat clinical imbalances that prevent the achievement of optimal health. This advanced diagnostic tool offers a systems-based approach for physicians, supporting patients in overcoming chronic conditions and adopting a healthier lifestyle.
Metabolomix+ evaluates a wide range of macronutrients and micronutrients, as well as markers that provide information about digestive function, toxin exposure, mitochondrial function, and oxidative stress. This is achieved through the assessment of organic acids, amino acids, fatty acids, oxidative stress markers, and nutritional and toxic elements.
Metabolomix+ provides an easy-to-use report with actionable clinical results, including:
▪️ Nutrient recommendations for key vitamins, minerals, amino acids, fatty acids, and digestive support, based on the functional evaluation of important biomarkers
▪️ Functional pillars with an integrated scoring system to guide therapy according to needs for methylation support, toxic exposures, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress
▪️ Quick-Interpretation pages that provide educational information about nutrient function, the causes and complications of deficiencies, and dietary sources
▪️ Dynamic biochemical pathway diagrams to provide a clear understanding of how certain biomarkers play a role in biochemistry
There are various methods for assessing nutrient status, including intracellular, extracellular, direct, and functional measurements. Each method has advantages and disadvantages. Metabolomix+ uses a combination of all these methods and synthesizes the information through an algorithm that determines personalized nutrient needs. The algorithm is based on functional markers that, according to the literature, are associated with the need for that specific nutrient.
What does Metabolomix+ test?
Organic acids:
▪️ Malabsorption and dysbiosis
▪️ Cellular energy and mitochondrial metabolites
▪️ Neurotransmitter metabolites
▪️ Vitamin markers
▪️ Toxins and detoxification markers
▪️ Tyrosine metabolism
▪️ New: oxalate markers
Amino acids:
▪️ Nutritionally essential amino acids
▪️ Non-essential protein amino acids
▪️ Intermediate metabolites
▪️ Markers related to dietary peptides
Other analyses:
▪️ Oxidative stress markers
▪️ Essential and metabolic fatty acids – Bloodspot (if selected as an additional profile)
▪️ Nutritional and toxic elements (if selected as an additional element)
What is a functional nutritional assessment?
A functional nutrition assessment analyzes metabolic intermediates produced in the enzymatic pathways of cellular energy production, detoxification, neurotransmitter breakdown, and amino acid metabolism. Elevated metabolite levels may indicate metabolic inhibition or blockage. This abnormality may be caused by nutrient deficiency, inherited enzyme defects, accumulation of toxic substances, or medication effects.
It is possible for a person to have normal blood levels of a vitamin to maintain homeostasis while simultaneously showing signs of functional insufficiency or deficiency. For this reason, direct testing of individual nutrients does not provide a complete picture.
What is included in the Metabolomix+ profile?
▪️ Organic acids provide insight into key metabolic irregularities related to potential nutritional cofactor needs, digestive irregularities, cellular energy production, neurotransmitter metabolism, and detoxification.
▪️ Oxidative stress markers indicate problems in two key areas: antioxidant capacity and oxidative damage. Oxidative stress is relevant for a wide range of clinical conditions and reflects the need to support antioxidant intervention and reduce free radical exposure.
▪️ Amino acids are important in many different clinical conditions. Metabolomix+ analyzes both essential and non-essential amino acids, as well as markers that may indicate impaired digestion, absorption, or metabolism of amino acids.
▪️ Fatty acids reflect the intake and metabolism of essential fatty acids, which are relevant for inflammatory balance, cell membrane fluidity, and cellular signaling.
▪️ Nutritional and toxic elements provide information about short-term exposure to toxins such as mercury, lead, cadmium, and arsenic, as well as direct evaluations of key minerals including magnesium, potassium, zinc, copper, and selenium.
Metabolism is a complex process that shows how vitamins, minerals, proteins, fats, and carbohydrates are used for thousands of essential biochemical reactions. Nutritional deficiencies can lead to biochemical disorders that impair healthy cell function and may contribute to disease.
Common clinical indications for testing
Many diseases are associated with abnormal levels of organic acids, amino acids, and fatty acids, including depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and others.
Conditions in which Metabolomix+ may provide additional insights include:
▪️ Mitochondrial dysfunction
▪️ Chronic stress
▪️ Inflammation
▪️ Mood disorders
▪️ Cardiovascular disease
▪️ Diabetes / insulin resistance / metabolic syndrome
▪️ Fatigue
▪️ Obesity / weight problems / need for dietary guidance
▪️ Malnutrition
▪️ Digestion and malabsorption
▪️ Cognitive decline
▪️ Athletic optimization
▪️ Increased nutrient demand in physical trauma and healing
Required sample:
Urine – FMV (first morning void)
Available add-ons:
1. Metabolomix+ Fatty Acids Add-On
Price: 550 RON
Manufacturer: Genova Diagnostics
Category: Fatty Acids / Metabolic Function
Sample Type: Bloodspot (finger prick)
Average Turnaround Time: 21 ± 5 days
Description
The Metabolomix+ Fatty Acids Add-On provides a comprehensive assessment of essential and metabolic fatty acid profiles using GC-MS (Gas Chromatography-Mass Spectrometry) technology from a dried blood spot sample collected via finger prick.
The panel evaluates the balance between different categories of fatty acids and provides valuable insights into inflammation, cardiovascular health, energy metabolism, cognitive function, and overall health status. When integrated with Metabolomix+ results, this add-on offers an expanded perspective on dietary fat intake, lipid metabolism, and factors involved in cardiometabolic health.
Analytes Covered
▪️ Omega-3 Fatty Acids
▪️ Omega-6 Fatty Acids
▪️ Omega-9 Fatty Acids
▪️ Saturated Fatty Acids
▪️ Monounsaturated Fatty Acids
▪️ Delta-6 Desaturase Activity
▪️ Cardiovascular Risk Markers
Clinical Applications
This test may provide useful information in the assessment of:
▪️ Cardiometabolic health and lipid balance
▪️ Chronic inflammatory processes
▪️ Persistent fatigue and energy levels
▪️ Cognitive function and concentration capacity
▪️ Mood and emotional well-being
▪️ Skin health (dry skin, eczema, inflammatory skin conditions)
▪️ Joint comfort and mobility
▪️ Dietary fat intake and Omega-3/Omega-6 balance
▪️ Metabolic health and weight management
▪️ Hormonal balance influenced by lipid metabolism
Sample Collection and Preparation
Sample Type: Bloodspot (finger prick)
Collection Instructions:
▪️ Fast for 12 hours prior to sample collection.
▪️ Do not consume any solid foods during the fasting period.
▪️ Water consumption is allowed.
▪️ Collect the sample in the morning, within 30 minutes of waking.
▪️ The sample must be collected before consuming any food or beverages (except water).
Important
This add-on can only be purchased together with the Metabolomix+ test.
2. Metabolomix+ Urine Elements Add-On
Price: 800 RON
Category: Metabolic Function / Toxic Metals
Sample Type: Urine
Average Turnaround Time: 21 ± 5 days
Description
The Metabolomix+ Urine Elements Add-On evaluates the urinary excretion of an extensive panel of nutritional elements and environmental toxic elements using ICP-MS (Inductively Coupled Plasma Mass Spectrometry) technology, based on a urine sample with results normalized to creatinine.
This add-on complements the Metabolomix+ analysis by assessing mineral status and potential exposure to toxic metals and environmental contaminants. Integrating these results with the metabolic, nutritional, and detoxification markers already included in Metabolomix+ can provide a broader perspective on nutritional balance, mineral metabolism, and the body's ability to manage environmental exposures.
Results are interpreted in the context of clinical history, dietary habits, lifestyle factors, occupational and environmental exposures, as well as the other biomarkers included in the Metabolomix+ assessment.
Toxic Elements Analyzed
Lead, Mercury, Aluminum, Antimony, Arsenic, Barium, Bismuth, Cadmium, Cesium, Gadolinium, Gallium, Nickel, Niobium (temporarily unavailable), Platinum, Rubidium, Thallium (temporarily unavailable), Thorium, Tin, Tungsten, Uranium.
Nutritional Elements Analyzed
Calcium, Chromium, Cobalt, Copper, Creatinine, Iron, Lithium, Magnesium, Manganese, Molybdenum, Selenium, Strontium, Sulfur, Vanadium, Zinc.
Clinical Applications
This test may provide useful information in the assessment of:
▪️ Exposure to heavy metals and environmental contaminants
▪️ Nutritional balance and mineral status
▪️ Persistent fatigue and reduced energy levels
▪️ Cognitive function and concentration capacity
▪️ Digestive health and food sensitivities
▪️ Neuromuscular symptoms (muscle cramps, weakness, altered coordination)
▪️ Changes affecting the skin, hair, and nails
▪️ Cardiometabolic health and energy metabolism
▪️ Processes associated with oxidative stress
▪️ Evaluation of markers involved in detoxification and toxin elimination
Sample Collection and Preparation
Sample Type: Urine
Collection instructions will be provided together with the testing kit.
Important
This add-on can only be purchased together with the Metabolomix+ test.